October 2023: New insights for breast cancer risk stratification

This new research underscores the need to consider both genetic and nongenetic factors for personalized risk assessment in breast cancer. The key findings are: 

* Genetic risk predictors, like polygenic risk scores (PRS), do not give the full picture for breast cancer risk stratification on their own.
* We explore the epigenome-genetic interaction at methylation quantitative trait loci (mQTLs).
* Methylation levels at mQTLs vary across cell types and with epidemiological characteristics, potentially revealing non-heritable risk dynamics.
* Our WID®-qtBC index, combining methylation values at 104 mQTL sites, may enhance breast cancer risk stratification beyond PRS.

EUTOPS Institute

Our vision is to integrate cutting-edge research in systems biology and oncology to enable real-world implementation of the concepts of P4 medicine (predictive, preventive, personalised and participatory) and drastically reduce cancer mortality.

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