The TirolGESUND study investigates the effect of lifestyle changes (smoking cessation or intermittent fasting with/without ketogenic dietary supplementation with guided, targeted exercise) on disease- and age-associated biological signatures and bodily functions.
The TirolGESUND study was a Multiomic Lifestyle Intervention Study (General Exercise, Smoking undone, and nutrition diet) involving 156 women aged 30-60 years in the Tirol.
The goal of this clinical study was to learn about disease-risk and age-associated changes in DNA methylation patterns associated with disease risk or age in healthy women in response to health-promoting lifestyle intervention (intermittent fasting or smoking cessation).
Participants were either allocated to a smoking cessation or dietary intervention arm based on inclusion criteria. Those in the dietary intervention group (16:8 hour intermittent fasting regime) were randomised to receive a ketogenic supplement or not. Comprehensive sample sets were collected at 2 month intervals during the intervention period, with optional follow-up visits at 12 and 18 months.
Data from the study in the form of a comprehensive Lifestyle Atlas and will be made openly available in due course.
The study is registered on ClinicalTrials.gov under NCT05678426 and on the ISRCTN under ISRCTN15374182.
This study has received funding from the European Union’s Horizon 2020 Research and Innovation programme [Grant Agreement No. 874662; HEAP], the Eve Appeal charity (eveappeal.org.uk) and the Land Tirol.
Partners
TirolGESUND is a collaborative project of several academic and clinical institutions in Tirol with over 20 partners.
Our vision is to integrate cutting-edge research in systems biology and oncology to enable real-world implementation of the concepts of P4 medicine (predictive, preventive, personalised and participatory) and drastically reduce cancer mortality.
We are a dynamic and international team with wide range of expertise.