With the LIFE and SUN Tyrol studies, we are launching two large-scale investigations to test interval fasting, exercise and stress reduction for their health-promoting effects (LIFE Tyrol) and to optimize smoking cessation (SUN Tyrol). Help us with your participation to make Tyrol a European pioneer region for preventive health care and prevention, so that all Tyroleans can enjoy as many healthy years of life as possible.


The LIFE Tirol study runs for 8 months and is aimed at non-smokers between the ages of 18 and 75 who are motivated to change their lifestyle.

Details of the LIFE TIROL study

At the beginning of the study, informed consent is obtained, a physical examination and sampling (cervical/vaginal swab, oral mucosa swab and blood), as well as measurement of arterial elasticity. This is followed by a questionnaire on the level of physical activity, as well as questionnaires on quality of life, quality of sleep and stress via the specially designed LIFE & SUN Tirol app.

Based on BMI and physical activity level (classification into no/low and high physical activity), subjects are randomly assigned to one of the following five groups: intermittent fasting (IF), exercise (excercise, EXC), stress reduction, relaxation and resilience training (wellbeing, WB) or combinations thereof (IF+EXC or IF+WB), for a better overview see the table below. The random assignment, also called randomization, is enormously important for the success of the study, because only in this way generally valid results are obtained, which can be transferred to the entire population. 
The participants will also initially receive a fitness tracker. They are not told at this stage which group they are in, but go through a two-month run-in phase where they continue their lives as before and at the end of which the same samples are taken again as at the beginning (plus urine and stool samples) and the same questionnaires are answered. In addition, the fitness tracker data is evaluated. Thus, in addition to the first visit, we have a second measured value, with which the average baseline values can be calculated. 
After two months, at the second visit, the subjects are told which group they are in and start the intervention.
In IF, after an introductory phase, subjects fast with their personal dietitian for 16 hours per day for 6 days per week. In a time interval from 06:00 hrs to 16:00 hrs, 8 hours can be chosen in which they eat food. No attention is paid to what is eaten. You will be asked to measure the ketone bodies yourself three times a week at home via a drop of blood from the fingertip before the first meal to check the measure. In addition, this measurement should be taken before the next three visits and a few drops of blood should also be dropped on a card. This is to determine the changes in the blood brought about by the intermittent fasting.
At EXC, according to the personal preferences of the participant:s, training plans are created with a:m personal reference trainer:in, which help them to increase their level of exercise. This is tracked on the one hand via the fitness tracker, and on the other hand via the documentation and weekly query of the exercise units via the app. Once a month, there is a video call with the:m reference trainer:in; in addition, they can always be reached via chat in case of questions or (motivation) problems.
The WB intervention aims to increase resilience, or psychological resistance. At a first personal meeting, a program is agreed upon based on the initial situation, after which modules can be activated in the app on an ongoing basis. A meeting with the reference psychologist takes place every two weeks.
The subjects with two interventions always start with fasting and after two months (i.e. 4 months from the start of the study) the second intervention is added, which is basically the same as the one described above.
The participants come every 2 months for examination and sampling and answer the questionnaires via the app. The study ends after a total of 8 months and 5 visits.


The SUN Tyrol study runs for 8 months and is aimed at smokers between 18 and 75 years of age who are motivated to give up smoking.

Details of the SUN TIROL study

At the beginning, smoking cessation takes place as part of the study in cooperation with the Addiction Support Tyrol. The test persons come to the first visit, where they give their consent to participate and are physically examined. Samples are taken (cervical/vaginal swab, oral mucosal swab and blood) and a measurement of arterial elasticity is performed.

In addition, questionnaires on quality of life, sleep and stress are answered via the specially designed LIFE & SUN Tirol app. Subsequently, the first of a total of three sessions of the Addiction Support Tyrol takes place. After one week, the second and third sessions take place online via the app and the smoking cessation process is completed. 
Starting with the first visit, the test persons come to the study center in Hall every two months (a total of five times) for examination and sample collection (starting with visit 2, they should also bring a urine and stool sample from home). In addition, participants will be randomly divided into two groups: one group will receive feedback on genetic markers that should normalize after smoking cessation every two months after the examination and the other group will not receive any information about this. This is to study the effect of the feedback on the sustainability of smoking cessation, that is, are the subjects more likely to remain smoke-free if they see that quitting smoking has positive effects. The study is completed after eight months. 

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